FGFR2 (N549H), active
N-terminal 6His-tagged recombinant, human FGFR2 (N549H) amino acids 456-770.
No items found.
Biological information
Background
Fibroblast growth factor (FGF) superfamily consists of 23 members, all of which contain a conserved 120 amino acid (aa) core region that contains six identical, interspersed amino acids. Based on the pI factor, two main groups of FGF are named: acidic FGF (aFGF) and basic FGF (bFGF). The superfamily members act extracellularly through four tyrosine kinase FGF receptors (FGR1 through FGR4), with multiple specificities noted for almost all FGFs. Biological binding of aFGF to its receptors will result in phosphorylation of the receptor and non-receptor proteins and generate its function. FGR2 (FGFR-2, Fibroblast growth factor receptor 2, Keratinocyte growth factor receptor 2, EC 2.7.1.112) is expressed mainly in bone, central nervous system, smooth muscle and tumors. Inhibition of FGR2 may inhibit cranial development and arterial repair as well as facilitate formation and proliferation of some tumors (e.g., prostate, thyroid).
GenBank NM_000141
Target class
Kinase
Family
TK
Accession number
NM_000141.3; NM_022970.2
Target Name
FGFR2 (N549H), active
Target Alias
FGFR2, CD332, JWS, FGFR-2, ECT1, CFD1, TK25, CEK3, TK14, BEK, KGFR, K-SAM, BFR-1, KSAM
Origin
Human
Theori. MW
38.1 kDa
Affinity tag
6His
Product specifications
Expression system
Expressed by baculovirus in Sf21 insect cells
Purity
Refer to CoA for Purity
Purification method
Ni2+/NTA-agarose
Sample Buffer
Protein in 6.3 μL of 50 mM Tris/HCl pH 7.5, 300 mM NaCl, 0.1 mM EGTA, 0.03% Brij 35, 270 mM sucrose, 1 mM benzamidine, 0.2 mM PMSF, 0.1% 2-mercaptoethanol. Frozen solution.
Specified activity
Refer to CoA
Application
For Research Only
Storage conditions
6 months at -70°C
Usage disclaimer
For Research Only
Chemical data
Background
Fibroblast growth factor (FGF) superfamily consists of 23 members, all of which contain a conserved 120 amino acid (aa) core region that contains six identical, interspersed amino acids. Based on the pI factor, two main groups of FGF are named: acidic FGF (aFGF) and basic FGF (bFGF). The superfamily members act extracellularly through four tyrosine kinase FGF receptors (FGR1 through FGR4), with multiple specificities noted for almost all FGFs. Biological binding of aFGF to its receptors will result in phosphorylation of the receptor and non-receptor proteins and generate its function. FGR2 (FGFR-2, Fibroblast growth factor receptor 2, Keratinocyte growth factor receptor 2, EC 2.7.1.112) is expressed mainly in bone, central nervous system, smooth muscle and tumors. Inhibition of FGR2 may inhibit cranial development and arterial repair as well as facilitate formation and proliferation of some tumors (e.g., prostate, thyroid).
GenBank NM_000141
Compound name
Kinase
Catalog number
14-742
Molecular formula
CAS
MW
Ka
Percent composition
Product specifications
Physical state
Purity (HPLC 214nm)
Retention time (RP18 HPLC)
CMC
Exact mass
Stability
For Research Only
Solubility structure
Datasheets
14-742
Datasheet