Fms (Y969C), active
N-terminal 6His-tagged recombinant, human Fms amino acids 538-end containing the mutation Y969C.
No items found.
Biological information
Background
CSF1R (colony stimulating factor I receptor), formerly known as FMS (McDonough feline sarcoma viral oncogene), is a receptor tyrosine kinase for CSF-1 and expressed primarily in monocytes, macrophages, and human tumor tissue. CSF-1 binding to FMS induces dimerization of the tyrosine kinase domain of the receptor, and stimulates the survival, proliferation, and differentiation of haematopoietic cells of the monocyte-macrophage series.
GenBank U63963
Target class
Kinase
Family
TK
Accession number
U63963
Target Name
Fms (Y969C), active
Target Alias
CSF1R, FIM2, CSF-1-R, C-FMS, CSFR, c-fms, CD115, FMS
Origin
Human
Theori. MW
50.2 kDa
Affinity tag
6His
Product specifications
Expression system
Expressed by baculovirus in Sf21 insect cells
Purity
Refer to CoA for Purity
Purification method
Ni2+/NTA-agarose
Sample Buffer
Protein in 50mM Tris/HCl pH7.5, 300mM NaCl, 0.1mM EGTA, 0.03% Brij-35, 270mM sucrose, 1mM benzamidine, 0.2mM PMSF, 0.1% 2-mercaptoethanol. Frozen solution.
Specified activity
Refer to CoA
Application
For Research Only
Storage conditions
6 months at -70°C
Usage disclaimer
For Research Only
Chemical data
Background
CSF1R (colony stimulating factor I receptor), formerly known as FMS (McDonough feline sarcoma viral oncogene), is a receptor tyrosine kinase for CSF-1 and expressed primarily in monocytes, macrophages, and human tumor tissue. CSF-1 binding to FMS induces dimerization of the tyrosine kinase domain of the receptor, and stimulates the survival, proliferation, and differentiation of haematopoietic cells of the monocyte-macrophage series.
GenBank U63963
Compound name
Kinase
Catalog number
14-820
Molecular formula
CAS
MW
Ka
Percent composition
Product specifications
Physical state
Purity (HPLC 214nm)
Retention time (RP18 HPLC)
CMC
Exact mass
Stability
For Research Only
Solubility structure
Datasheets
14-820
Datasheet