Aurora B, active
6His-tagged recombinant, human full length Aurora B and N-terminal GST-tagged recombinant, human INCENP amino acids 821-end.
No items found.
Biological information
Background
Aurora family of kinases, contained at least three proteins (Aurora A, B and C), phosphorylate histone H3 and provide a direct path to the nucleosome. Aurora-B (AURAKB, AIK2, AIM1, ARK2, STK12) is needed for metaphase alignment of chromosomes, sister chromatid separation and cytokinesis. Overexpression of Aurora-B is found in several types of cancer and causes dramatic increases in genomic instability.
GenBank NM_004217 / GenBank NM_020238
Target class
Kinase
Family
AGC
Accession number
NM_004217
Target Name
Aurora B, active
Target Alias
AIM-1, STK12, Aik2, IPL1, Aurora-B, ARK2, aurora-B, AIK2, AIM1, AurB, STK5, aurora-1, STK-1, AURKB
Origin
Human
Theori. MW
40 kDa (Aurora B), 38 kDa (INCENP)
Affinity tag
GST
Product specifications
Expression system
Expressed by baculovirus in Sf21 insect cells
Purity
Refer to CoA for Purity
Purification method
Glutathione agarose affinity chromatography
Sample Buffer
Specified activity
Refer to CoA
Application
For Research Only
Storage conditions
6 months at -70°C
Usage disclaimer
For Research Only
Chemical data
Background
Aurora family of kinases, contained at least three proteins (Aurora A, B and C), phosphorylate histone H3 and provide a direct path to the nucleosome. Aurora-B (AURAKB, AIK2, AIM1, ARK2, STK12) is needed for metaphase alignment of chromosomes, sister chromatid separation and cytokinesis. Overexpression of Aurora-B is found in several types of cancer and causes dramatic increases in genomic instability.
GenBank NM_004217 / GenBank NM_020238
Compound name
Kinase
Catalog number
14-835
Molecular formula
CAS
MW
Ka
Percent composition
Product specifications
Physical state
Purity (HPLC 214nm)
Retention time (RP18 HPLC)
CMC
Exact mass
Stability
For Research Only
Solubility structure
Datasheets
14-835
Datasheet