Aurora C, active
N-terminal 6His-tagged recombinant, human Aurora C amino acids 35-end and N-terminal GST-tagged recombinant, human INCENP amino acids 821-end.
No items found.
Biological information
Background
Aurora C Protein is a member of the Aurora subfamily of serine/threonine protein kinases. It is a chromosomal passenger protein that forms complexes with Aurora-B and inner centromere proteins and may play a role in organizing microtubules in relation to centrosome/spindle function during mitosis. This gene is overexpressed in several cancer cell lines, suggesting an involvement in oncogenic signal transduction. Alternative splicing results in multiple transcript variants.
GenBank AB017332.1 / GenBank NM_020238.2
Target class
Kinase
Family
AGC
Accession number
NP_001015878
Target Name
Aurora C, active
Target Alias
AIK32 3 , ARK-3, STK13, ARK3, AurC
Origin
Human
Theori. MW
36 kDa (Aurora C), 38 kDa (INCENP)
Affinity tag
GST, 6His
Product specifications
Expression system
Expressed by baculovirus in Sf21 insect cells
Purity
Combined purity 94% by SDS-PAGE and Coomassie blue staining.
Purification method
Ni2+/NTA-agarose
Sample Buffer
Specified activity
Refer to CoA
Application
For Research Only
Storage conditions
6 months at -70°C
Usage disclaimer
For Research Only
Chemical data
Background
Aurora C Protein is a member of the Aurora subfamily of serine/threonine protein kinases. It is a chromosomal passenger protein that forms complexes with Aurora-B and inner centromere proteins and may play a role in organizing microtubules in relation to centrosome/spindle function during mitosis. This gene is overexpressed in several cancer cell lines, suggesting an involvement in oncogenic signal transduction. Alternative splicing results in multiple transcript variants.
GenBank AB017332.1 / GenBank NM_020238.2
Compound name
Kinase
Catalog number
14-911
Molecular formula
CAS
MW
Ka
Percent composition
Product specifications
Physical state
Purity (HPLC 214nm)
Retention time (RP18 HPLC)
CMC
Exact mass
Stability
For Research Only
Solubility structure
Datasheets
14-911
Datasheet