DCAMKL3, active
N-terminal 6His-tagged recombinant, human DCAMKL3 amino acids 345-end.
No items found.
Biological information
Background
DCAMKL3 (Doublecortin and CaM Kinase-Like 3), also known as microtubule affinity-regulating kinase 3 (MARK3), is a serine/threonine protein kinase that belongs to the CAMK (calcium/calmodulin-dependent protein kinase) family of kinases. It is involved in a variety of cellular processes, including regulation of microtubule dynamics, cell polarity, and cell migration. Research has suggested that DCAMKL3 plays a role in several diseases, including cancer and Alzheimer's disease. In cancer, DCAMKL3 has been shown to promote tumor growth and metastasis, and inhibition of DCAMKL3 has been suggested as a potential cancer therapy. In Alzheimer's disease, DCAMKL3 has been implicated in the regulation of tau phosphorylation and aggregation, and alterations in DCAMKL3 expression have been observed in the brains of Alzheimer's disease patients.
Target class
Kinase
Family
CAMK
Accession number
NM_033403
Target Name
DCAMKL3, active
Target Alias
Origin
Human
Theori. MW
38 kDa
Affinity tag
6His
Product specifications
Expression system
Expressed by baculovirus in Sf21 insect cells
Purity
Purity 97% by SDS-PAGE and Coomassie blue staining.
Purification method
Immobilised metal affinity chromatography
Sample Buffer
Protein in 50mM Tris/HCl pH7.5, 300mM NaCl, 0.1mM EGTA, 0.03% Brij-35, 270mM sucrose, 1mM benzamidine, 0.2mM PMSF, 0.1% 2-mercaptoethanol. Frozen solution.
Specified activity
Refer to CoA
Application
For Research Only
Storage conditions
1 year at -70°C
Usage disclaimer
For Research Only
Chemical data
Background
DCAMKL3 (Doublecortin and CaM Kinase-Like 3), also known as microtubule affinity-regulating kinase 3 (MARK3), is a serine/threonine protein kinase that belongs to the CAMK (calcium/calmodulin-dependent protein kinase) family of kinases. It is involved in a variety of cellular processes, including regulation of microtubule dynamics, cell polarity, and cell migration. Research has suggested that DCAMKL3 plays a role in several diseases, including cancer and Alzheimer's disease. In cancer, DCAMKL3 has been shown to promote tumor growth and metastasis, and inhibition of DCAMKL3 has been suggested as a potential cancer therapy. In Alzheimer's disease, DCAMKL3 has been implicated in the regulation of tau phosphorylation and aggregation, and alterations in DCAMKL3 expression have been observed in the brains of Alzheimer's disease patients.
Compound name
Kinase
Catalog number
14-943
Molecular formula
CAS
MW
Ka
Percent composition
Product specifications
Physical state
Purity (HPLC 214nm)
Retention time (RP18 HPLC)
CMC
Exact mass
Stability
For Research Only
Solubility structure
Datasheets
14-943
Datasheet