ATR/ATRIP, active
Recombinant, human FLAG-tagged ATR full length and recombinant, human cMyc-tagged ATRIP full length.
No items found.
Biological information
Background
Serine/threonine-protein kinase ATR activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. ATR interacts with the ataxia telangiectasia and Rad3 related protein kinase, resulting in its accumulation at intranuclear foci induced by DNA damage.
GenBank NM_001184.3* / GenBank AF451323.1 * Note: the recombinant ATR contains the amino acid substitution M211T with reference toGenBank NM_001184.3. M211T is reported inGenBank XM_001131387.1.
Target class
Kinase
Family
PI3/PI4-Kinase
Accession number
NM_001184.3; AF451323.1
Target Name
ATR/ATRIP, active
Target Alias
Origin
Human
Theori. MW
303 kDa (ATR), 87 kDa (ATRIP)
Affinity tag
FLAG, c-Myc
Product specifications
Expression system
Expressed in a mammalian cell line
Purity
Purity 50% by SDS-PAGE and Coomassie blue staining.
Purification method
Sample Buffer
Specified activity
Refer to CoA
Application
For Research Only
Storage conditions
1 year at -70°C
Usage disclaimer
For Research Only
Chemical data
Background
Serine/threonine-protein kinase ATR activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. ATR interacts with the ataxia telangiectasia and Rad3 related protein kinase, resulting in its accumulation at intranuclear foci induced by DNA damage.
GenBank NM_001184.3* / GenBank AF451323.1 * Note: the recombinant ATR contains the amino acid substitution M211T with reference toGenBank NM_001184.3. M211T is reported inGenBank XM_001131387.1.
Compound name
Kinase
Catalog number
14-953
Molecular formula
CAS
MW
Ka
Percent composition
Product specifications
Physical state
Purity (HPLC 214nm)
Retention time (RP18 HPLC)
CMC
Exact mass
Stability
For Research Only
Solubility structure
Datasheets
14-953
Datasheet