CaM Kinase I γ, active

CaM Kinase I γ (Calcium/Calmodulin-Dependent Protein Kinase I gamma) is a serine/threonine protein kinase that belongs to the CaM Kinase family of kinases. It is primarily expressed in the brain, where it plays a critical role in neuronal signaling and plasticity. CaM Kinase I γ is activated by binding of calcium and calmodulin, which leads to autophosphorylation and activation of the kinase. It has been shown to phosphorylate a variety of substrates, including ion channels, transcription factors, and other kinases, which contributes to the regulation of neuronal excitability, gene expression, and synaptic plasticity. Research has suggested that CaM Kinase I γ plays a critical role in several neurological and psychiatric disorders, including Alzheimer's disease, schizophrenia, and bipolar disorder.