DYRK3, active
N-terminal GST-tagged and C-terminal 6His tagged, recombinant, human DYRK3 full length, expressed by baculovirus in Sf21 insect cells. Purified using immobilized metal affinity chromatography.
Biological information
Background
DYRK3 (Dual-specificity Tyrosine Phosphorylation-Regulated Kinase 3) is a serine/threonine protein kinase that belongs to the DYRK (dual-specificity tyrosine-phosphorylation regulated kinase) family of kinases. It is involved in a variety of cellular processes, including regulation of the cell cycle, DNA damage response, and apoptosis. Research has suggested that DYRK3 plays a role in several diseases, including cancer, neurodegenerative diseases, and viral infections. In cancer, DYRK3 has been shown to contribute to tumor growth and survival, and inhibition of DYRK3 has been suggested as a potential cancer therapy. In neurodegenerative diseases, DYRK3 has been implicated in the regulation of neuronal survival and degeneration, and alterations in DYRK3 expression and activity have been observed in the brains of patients with Alzheimer's disease and Parkinson's disease. Additionally, inhibition of DYRK3 has been suggested as a potential therapeutic strategy for viral infections.
Target class
Kinase
Family
CMGC
Accession number
NM_003582.2
Target Name
DYRK3, active
Target Alias
Origin
Human
Theori. MW
94 kDa
Affinity tag
GST
Product specifications
Expression system
Expressed by baculovirus in Sf21 insect cells
Purity
Purity 85% by SDS-PAGE and Coomassie blue staining.
Purification method
Immobilized metal affinity chromatography
Sample Buffer
0.52 mg/ml of enzyme in 50 mM Tris/HCl pH7.5, 300 mM NaCl, 0.1 mM EGTA, 0.03% Brij-35, 270 mM sucrose, 1 mM benzamidine, 0.2 mM PMSF, 0.1% 2-mercaptoethanol. Frozen solution.
Specified activity
Refer to CoA
Application
For Research Only
Storage conditions
1 year at -70°C
Usage disclaimer
For Research Only
Chemical data
Background
DYRK3 (Dual-specificity Tyrosine Phosphorylation-Regulated Kinase 3) is a serine/threonine protein kinase that belongs to the DYRK (dual-specificity tyrosine-phosphorylation regulated kinase) family of kinases. It is involved in a variety of cellular processes, including regulation of the cell cycle, DNA damage response, and apoptosis. Research has suggested that DYRK3 plays a role in several diseases, including cancer, neurodegenerative diseases, and viral infections. In cancer, DYRK3 has been shown to contribute to tumor growth and survival, and inhibition of DYRK3 has been suggested as a potential cancer therapy. In neurodegenerative diseases, DYRK3 has been implicated in the regulation of neuronal survival and degeneration, and alterations in DYRK3 expression and activity have been observed in the brains of patients with Alzheimer's disease and Parkinson's disease. Additionally, inhibition of DYRK3 has been suggested as a potential therapeutic strategy for viral infections.
Compound name
Kinase
Catalog number
15-002
Molecular formula
CAS
MW
Ka
Percent composition
Product specifications
Physical state
Purity (HPLC 214nm)
Retention time (RP18 HPLC)
CMC
Exact mass
Stability
For Research Only
Solubility structure
Datasheets
15-002
Datasheet