BMPR2, active
10 µg of active BMPR2. N-terminal 6His-tagged, recombinant fragment of human BMPR2.
Biological information
Background
Bone Morphogenetic Protein Receptor Type 2 (BMPR2) is a member of the bone morphogenetic protein receptor family of transmembrane serine/threonine kinases. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of two different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Mutations in this gene have been associated with primary pulmonary hypertension, both familial and fenfluramine-associated, and with pulmonary venoocclusive disease. [provided by RefSeq, May 2020]
Target class
Kinase
Family
TKL
Accession number
NM001204.7
Target Name
BMPR2, active
Target Alias
Bone Morphogenetic Protein Receptor Type 2; BMPR-II; Bone Morphogenetic Protein Receptor Type II; BRK-3; BMPR3; PPH1
Origin
Human
Theori. MW
67 kDa
Affinity tag
6His
Product specifications
Expression system
Expressed by baculovirus in Sf21 insect cells
Purity
83% by SDS-PAGE and Coomassie blue staining
Purification method
Immobilized metal affinity chromatography
Sample Buffer
1.85 mg/ml of enzyme in 40 mM Tris/HCl pH 7.5, 40 mM NaCl, 240 mM imidazole, 0.08 mM EGTA, 20% (v/v) glycerol. Frozen solution.
Specified activity
Refer to CoA
Application
For Research Only
Storage conditions
1 year at -70°C.
Usage disclaimer
For Research Only
Chemical data
Background
Bone Morphogenetic Protein Receptor Type 2 (BMPR2) is a member of the bone morphogenetic protein receptor family of transmembrane serine/threonine kinases. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of two different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Mutations in this gene have been associated with primary pulmonary hypertension, both familial and fenfluramine-associated, and with pulmonary venoocclusive disease. [provided by RefSeq, May 2020]
Compound name
Kinase
Catalog number
16-001
Molecular formula
CAS
MW
Ka
Percent composition
Product specifications
Physical state
Purity (HPLC 214nm)
Retention time (RP18 HPLC)
CMC
Exact mass
Stability
For Research Only
Solubility structure
Datasheets
16-001
Datasheet