CRIK, active
10 µg of active CRIK. N-terminal GST-tagged, recombinant, human CRIK amino acids 1-449.
Biological information
Background
CRIK, also known as Citron Rho-Interacting Serine/Threonine Kinase, is a serine/threonine-protein kinase that functions in cell division. Together with the kinesin KIF14, this protein localizes to the central spindle and midbody, and functions to promote efficient cytokinesis. This protein is involved in central nervous system development. Polymorphisms in this gene are associated with bipolar disorder and risk for schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
Target class
Kinase
Family
AGC
Accession number
NM_007174.2
Target Name
CRIK, active
Target Alias
Citron Rho-Interacting Serine/Threonine Kinase; CIT; STK21; CITK; Citron (Rho-Interacting, Serine/Threonine Kinase 21)
Origin
Human
Theori. MW
77 kDa
Affinity tag
GST
Product specifications
Expression system
Expressed by baculovirus in Sf21 insect cells
Purity
93% by SDS-PAGE and Coomassie blue staining.
Purification method
glutathione agarose
Sample Buffer
0.86mg/ml of enzyme in 50mM Tris/HCl pH7.5, 300mM NaCl, 0.1mM EGTA, 0.03% Brij-35, 270mM sucrose, 1mM benzamidine, 0.2mM PMSF, 0.1% 2-mercaptoethanol. Frozen solution.
Specified activity
Refer to CoA
Application
For Research Only
Storage conditions
1 year at -70°C.
Usage disclaimer
For Research Only
Chemical data
Background
CRIK, also known as Citron Rho-Interacting Serine/Threonine Kinase, is a serine/threonine-protein kinase that functions in cell division. Together with the kinesin KIF14, this protein localizes to the central spindle and midbody, and functions to promote efficient cytokinesis. This protein is involved in central nervous system development. Polymorphisms in this gene are associated with bipolar disorder and risk for schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
Compound name
Kinase
Catalog number
16-040
Molecular formula
CAS
MW
Ka
Percent composition
Product specifications
Physical state
Purity (HPLC 214nm)
Retention time (RP18 HPLC)
CMC
Exact mass
Stability
For Research Only
Solubility structure
Datasheets
16-040
Datasheet