Parkin (c-Myc tagged), active
N-Terminal c-Myc and 6His-tagged, recombinant, human Parkin, full length, expressed by baculovirus in Sf21 insect cells.
Biological information
Background
Parkin plays a critical role in the regulation of cellular responses to stress and the maintenance of cellular homeostasis. Parkin is particularly important for the regulation of mitochondrial quality control, which involves the selective removal of damaged or dysfunctional mitochondria through a process called mitophagy. Parkin has also been implicated in the regulation of other cellular processes, such as the cell cycle, apoptosis, and the immune response. Mutations in the parkin gene have been linked to the development of Parkinson's disease. Research on Parkin and its role in cellular regulation and disease pathology is ongoing, and may lead to the development of new therapies for Parkinson's disease and other disorders associated with mitochondrial dysfunction.
Target class
Ubiquitin
Family
E3
Accession number
GenBank NM_004562
Target Name
Parkin (c-Myc tagged), active
Target Alias
AR-JP, LPRS2, PARK2, PDJ
Origin
Human
Theori. MW
57 kDa
Affinity tag
N-terminal c-Myc, 6His-tag
Product specifications
Expression system
expressed in insect cells
Purity
94%
Purification method
Immobilized metal affinity chromatography
Sample Buffer
2.15 mg/ml of enzyme in a buffer containing 50 mM Tris/HCl pH 7.5, 150 mM NaCl, 0.03% Brij-35, 270 mM sucrose, 1 mM benzamidine, 0.2 mM PMSF, 0.1% 2-mercaptoethanol. Frozen solution.
Specified activity
Refer to CoA
Application
For Research Only
Storage conditions
1 year at -70°C
Usage disclaimer
For Research Only
Chemical data
Background
Parkin plays a critical role in the regulation of cellular responses to stress and the maintenance of cellular homeostasis. Parkin is particularly important for the regulation of mitochondrial quality control, which involves the selective removal of damaged or dysfunctional mitochondria through a process called mitophagy. Parkin has also been implicated in the regulation of other cellular processes, such as the cell cycle, apoptosis, and the immune response. Mutations in the parkin gene have been linked to the development of Parkinson's disease. Research on Parkin and its role in cellular regulation and disease pathology is ongoing, and may lead to the development of new therapies for Parkinson's disease and other disorders associated with mitochondrial dysfunction.
Compound name
Ubiquitin
Catalog number
23-046
Molecular formula
CAS
MW
Ka
Percent composition
Product specifications
Physical state
Purity (HPLC 214nm)
Retention time (RP18 HPLC)
CMC
Exact mass
Stability
For Research Only
Solubility structure
Datasheets
23-046
Datasheet