Cardiac Troponin I
N-Terminal c-Myc and GST-tagged, recombinant, human Cardiac Troponin I, full length, expressed by baculovirus in Sf21 insect cells.
Biological information
Background
Cardiac Troponin I (cTnI) is a protein that is exclusively expressed in cardiac muscle cells. It is a component of the troponin complex, which is responsible for regulating the contraction and relaxation of cardiac muscle. cTnI is a highly specific and sensitive biomarker for diagnosing acute coronary syndromes (ACS), including MI.
In addition to its diagnostic utility, cTnI is also used to assess the prognosis of patients with ACS and to monitor their response to treatment. Elevated levels of cTnI are associated with a higher risk of adverse cardiovascular events, such as heart failure and death. Therefore, monitoring cTnI levels over time can help healthcare professionals to predict the likelihood of these events and adjust treatment accordingly.
Target class
Ubiquitin
Family
Substrate
Accession number
GenBank NM_000363
Target Name
Cardiac Troponin I
Target Alias
CMD1FF, CMD2A, CMH7, RCM1, TNNC1, cTnI
Origin
Human
Theori. MW
52 kDa
Affinity tag
N-terminal c-Myc, GST-tag
Product specifications
Expression system
expressed in insect cells
Purity
68%
Purification method
Glutathione sepharose
Sample Buffer
0.40 mg/ml of enzyme in 50 mM Tris/HCl pH 7.5, 150 mM NaCl, 0.1 mM EGTA, 0.03% Brij-35, 270 mM sucrose, 1 mM benzamidine, 0.2 mM PMSF, 0.1% 2-mercaptoethanol. Frozen solution.
Specified activity
Refer to CoA
Application
For Research Only
Storage conditions
1 year at -70°C
Usage disclaimer
For Research Only
Chemical data
Background
Cardiac Troponin I (cTnI) is a protein that is exclusively expressed in cardiac muscle cells. It is a component of the troponin complex, which is responsible for regulating the contraction and relaxation of cardiac muscle. cTnI is a highly specific and sensitive biomarker for diagnosing acute coronary syndromes (ACS), including MI.
In addition to its diagnostic utility, cTnI is also used to assess the prognosis of patients with ACS and to monitor their response to treatment. Elevated levels of cTnI are associated with a higher risk of adverse cardiovascular events, such as heart failure and death. Therefore, monitoring cTnI levels over time can help healthcare professionals to predict the likelihood of these events and adjust treatment accordingly.
Compound name
Ubiquitin
Catalog number
23-055
Molecular formula
CAS
MW
Ka
Percent composition
Product specifications
Physical state
Purity (HPLC 214nm)
Retention time (RP18 HPLC)
CMC
Exact mass
Stability
For Research Only
Solubility structure
Datasheets
23-055
Datasheet