STEAP2, Active Protein
Six Transmembrane Epithelial Antigen of the Prostate 2
Biological information
STEAP2 is a member of the STEAP (Six Transmembrane Epithelial Antigen of the Prostate) hemoproteins exhibiting metal ion reductase activities. STEAP2 has a high level of expression in protaste epithelial cells and is located at the plasma membrane, golgi complex, trans golgi network (TGN) and early endosomes. STEAP2 works as a shuttle between Golgi and plasma membrane, contributing to Fe3+ and Cu2+ uptake and reduction, facilitating transferrin cycle. Moreover, its association with early endosomes and the TGN suggest its implication in protein delivery and sorting mechansims. STEAP2 is highly over expressed in prostate cancer cells, promoting tumors proliferation by modulating aggressive prostate cancer traits such as cell migration and invasion. Even if STEAP2 shows promise as a potential novel therapeutic target, no treatment has been developed to date.
Product specifications
Chemical data
STEAP2 is a member of the STEAP (Six Transmembrane Epithelial Antigen of the Prostate) hemoproteins exhibiting metal ion reductase activities. STEAP2 has a high level of expression in protaste epithelial cells and is located at the plasma membrane, golgi complex, trans golgi network (TGN) and early endosomes. STEAP2 works as a shuttle between Golgi and plasma membrane, contributing to Fe3+ and Cu2+ uptake and reduction, facilitating transferrin cycle. Moreover, its association with early endosomes and the TGN suggest its implication in protein delivery and sorting mechansims. STEAP2 is highly over expressed in prostate cancer cells, promoting tumors proliferation by modulating aggressive prostate cancer traits such as cell migration and invasion. Even if STEAP2 shows promise as a potential novel therapeutic target, no treatment has been developed to date.