DOT1L

DOT1L (disruptor of telomeric silencing 1-like) is an epigenetic protein that functions as a histone methyltransferase. It is responsible for adding methyl groups to specific lysine residues on histones, leading to the formation of heterochromatin and repression of gene expression. DOT1L is widely expressed in many tissues and is important for normal development and cellular function. It is involved in various biological processes, including transcriptional regulation, DNA damage response, and cell cycle progression. Aberrant DOT1L activity has been implicated in various diseases, including cancer, leukemia, and neurodevelopmental disorders. DOT1L inhibitors are being developed for therapeutic purposes, and understanding its function is important for developing new therapies.