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G9a

Recombinant human G9a amino acids 913-1193.

Biological information

Background
G9a is an epigenetic protein that plays an important role in regulating gene expression by modifying the structure of chromatin, the material that makes up chromosomes. Specifically, G9a is a histone methyltransferase, which means it adds chemical modifications (methyl groups) to histone proteins. Histones are the proteins around which DNA is coiled, and modifications to histones can either promote or inhibit gene expression, depending on the location and type of modification. G9a primarily adds methyl groups to histone H3 at a specific location called lysine 9 (hence the name G9a). This modification, known as H3K9me2, is associated with a more compact chromatin structure that typically represses gene expression. Therefore, G9a is often considered a gene silencer. G9a has been implicated in a variety of biological processes, including embryonic development, stem cell differentiation, and cancer.
Target class
Epigenetic
Family
Accession number
NP_006700.2
Target Name
G9a
Target Alias
BAT8, EHMT2, HLA-B, NG36
Origin
Human
Theori. MW
32.6 kDa
Affinity tag
Thrombin protease

Product specifications

Expression system
Expressed in E. coli
Purity
Refer to CoA for Purity
Purification method
Immobilised metal affinity chromatography
Sample Buffer
Protein in 5mM Tris/HCl pH7.5, 250mM NaCl, 50% glycerol. Frozen solution
Specified activity
Refer to CoA
Application
For Research Only
Storage conditions
1 year at -70°C.
Usage disclaimer
For Research Only

Chemical data

Background
G9a is an epigenetic protein that plays an important role in regulating gene expression by modifying the structure of chromatin, the material that makes up chromosomes. Specifically, G9a is a histone methyltransferase, which means it adds chemical modifications (methyl groups) to histone proteins. Histones are the proteins around which DNA is coiled, and modifications to histones can either promote or inhibit gene expression, depending on the location and type of modification. G9a primarily adds methyl groups to histone H3 at a specific location called lysine 9 (hence the name G9a). This modification, known as H3K9me2, is associated with a more compact chromatin structure that typically represses gene expression. Therefore, G9a is often considered a gene silencer. G9a has been implicated in a variety of biological processes, including embryonic development, stem cell differentiation, and cancer.
Compound name
Epigenetic
Catalog number
EPI022
Molecular formula
CAS
MW
Ka
Percent composition

Product specifications

Physical state
Purity (HPLC 214nm)
Retention time (RP18 HPLC)
CMC
Exact mass
Stability
For Research Only
Solubility structure
Datasheets
EPI022
Datasheet
€ 489,00 EUR
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