HAT1
N-terminal 6His-tagged recombinant, human HAT1 amino acids 20-341.
Biological information
Background
HAT1 (histone acetyltransferase 1) is an enzyme that adds acetyl groups to histone proteins. Histones are the proteins that package DNA into chromatin, and acetylation is a type of post-translational modification that can modify the structure of chromatin and influence gene expression. Specifically, acetylation of histones is associated with a more open chromatin structure that allows for greater access to DNA by transcription factors and other proteins, leading to increased gene expression. HAT1 is conserved across a wide range of organisms, from yeast to humans, and has been shown to play an important role in various cellular processes, including DNA replication, repair, and cell cycle regulation. Dysregulation of HAT1 has been linked to various diseases, including cancer and neurological disorders. Therefore, HAT1 has emerged as a potential target for therapeutic interventions.
Target class
Epigenetic
Family
Accession number
NP_003633.1
Target Name
HAT1
Target Alias
KAT1
Origin
Human
Theori. MW
39.8 kDa
Affinity tag
6His
Product specifications
Expression system
Expressed in E. coli
Purity
Refer to CoA for Purity
Purification method
Immobilised metal affinity chromatography
Sample Buffer
Protein in 25mM Tris/HCl pH7.5,
125mM NaCl, 0.3mM DTT, 50% Glycerol. Frozen solution.
Specified activity
Refer to CoA
Application
For Research Only
Storage conditions
1 year at -70°C.
Usage disclaimer
For Research Only
Chemical data
Background
HAT1 (histone acetyltransferase 1) is an enzyme that adds acetyl groups to histone proteins. Histones are the proteins that package DNA into chromatin, and acetylation is a type of post-translational modification that can modify the structure of chromatin and influence gene expression. Specifically, acetylation of histones is associated with a more open chromatin structure that allows for greater access to DNA by transcription factors and other proteins, leading to increased gene expression. HAT1 is conserved across a wide range of organisms, from yeast to humans, and has been shown to play an important role in various cellular processes, including DNA replication, repair, and cell cycle regulation. Dysregulation of HAT1 has been linked to various diseases, including cancer and neurological disorders. Therefore, HAT1 has emerged as a potential target for therapeutic interventions.
Compound name
Epigenetic
Catalog number
EPI025
Molecular formula
CAS
MW
Ka
Percent composition
Product specifications
Physical state
Purity (HPLC 214nm)
Retention time (RP18 HPLC)
CMC
Exact mass
Stability
For Research Only
Solubility structure
Datasheets
EPI025
Datasheet