JMJD2A
N-terminal 6His-tagged recombinant amino acids 1-359, human JMJD2A.
Biological information
Background
JMJD2A (Jumonji domain-containing protein 2A) is an epigenetic protein that functions as a histone demethylase. It is responsible for removing methyl groups from specific lysine residues on histones, leading to the formation of euchromatin and activation of gene expression. JMJD2A is widely expressed in many tissues and is important for normal development and cellular function. It is involved in various biological processes, including transcriptional regulation, DNA damage response, and cell cycle progression. Aberrant JMJD2A activity has been implicated in various diseases, including cancer, neurological disorders, and cardiovascular diseases. JMJD2A inhibitors are being developed for therapeutic purposes, and understanding its function is important for developing new therapies.
Target class
Epigenetic
Family
Accession number
NP_055478.2
Target Name
JMJD2A
Target Alias
JHDM3A, KDM4A, KIAA0677
Origin
Human
Theori. MW
44.3 kDa
Affinity tag
6His
Product specifications
Expression system
Expressed in E. coli
Purity
Refer to CoA for Purity
Purification method
Immobilised metal affinity chromatography
Sample Buffer
Protein in 25mM Hepes/NaOH pH
7.4, 250mM NaCl, 50% glycerol. Frozen solution.
Specified activity
Refer to CoA
Application
For Research Only
Storage conditions
1 year at -70°C.
Usage disclaimer
For Research Only
Chemical data
Background
JMJD2A (Jumonji domain-containing protein 2A) is an epigenetic protein that functions as a histone demethylase. It is responsible for removing methyl groups from specific lysine residues on histones, leading to the formation of euchromatin and activation of gene expression. JMJD2A is widely expressed in many tissues and is important for normal development and cellular function. It is involved in various biological processes, including transcriptional regulation, DNA damage response, and cell cycle progression. Aberrant JMJD2A activity has been implicated in various diseases, including cancer, neurological disorders, and cardiovascular diseases. JMJD2A inhibitors are being developed for therapeutic purposes, and understanding its function is important for developing new therapies.
Compound name
Epigenetic
Catalog number
EPI029
Molecular formula
CAS
MW
Ka
Percent composition
Product specifications
Physical state
Purity (HPLC 214nm)
Retention time (RP18 HPLC)
CMC
Exact mass
Stability
For Research Only
Solubility structure
Datasheets
EPI029
Datasheet