SETD2
N-terminal 6His-tagged recombinant, human SETD2 amino acids 843-1208.
Biological information
Background
SETD2 (SET Domain Containing 2) is a histone methyltransferase that catalyzes the transfer of a methyl group from S-adenosylmethionine (SAM) to the lysine 36 residue of histone H3 (H3K36), leading to the formation of mono-, di-, and trimethylated H3K36. SETD2 is a member of the SET domain-containing protein family and is the only known enzyme that specifically methylates H3K36. SETD2 plays a crucial role in the regulation of transcriptional elongation by methylating H3K36 on actively transcribed genes, and it is involved in the recruitment of transcriptional elongation factors, including FACT and the PAF complex. SETD2 is an important epigenetic protein with potential therapeutic applications. Its inhibition has been shown to suppress tumor growth and improve the response to chemotherapy in preclinical models of cancer.
Target class
Epigenetic
Family
Accession number
AAI17163.1
Target Name
SETD2
Target Alias
Origin
Human
Theori. MW
44.1 kDa
Affinity tag
6His
Product specifications
Expression system
Expressed in E. coli
Purity
Refer to CoA for Purity
Purification method
Immobilised metal affinity chromatography
Sample Buffer
Protein in 5mM Tris/HCl pH7.5,
250mM NaCl, 50% Glycerol, 1.4mM DTT. Frozen solution.
Specified activity
Refer to CoA
Application
For Research Only
Storage conditions
1 year at -70°C.
Usage disclaimer
For Research Only
Chemical data
Background
SETD2 (SET Domain Containing 2) is a histone methyltransferase that catalyzes the transfer of a methyl group from S-adenosylmethionine (SAM) to the lysine 36 residue of histone H3 (H3K36), leading to the formation of mono-, di-, and trimethylated H3K36. SETD2 is a member of the SET domain-containing protein family and is the only known enzyme that specifically methylates H3K36. SETD2 plays a crucial role in the regulation of transcriptional elongation by methylating H3K36 on actively transcribed genes, and it is involved in the recruitment of transcriptional elongation factors, including FACT and the PAF complex. SETD2 is an important epigenetic protein with potential therapeutic applications. Its inhibition has been shown to suppress tumor growth and improve the response to chemotherapy in preclinical models of cancer.
Compound name
Epigenetic
Catalog number
EPI055
Molecular formula
CAS
MW
Ka
Percent composition
Product specifications
Physical state
Purity (HPLC 214nm)
Retention time (RP18 HPLC)
CMC
Exact mass
Stability
For Research Only
Solubility structure
Datasheets
EPI055
Datasheet