Sirtuin 2
N-terminal 6His-tagged recombinant amino acids 50-356, human sirtuin 2.
Biological information
Background
Sirtuin 2 (SIRT2) is a member of the Sirtuin family of NAD+-dependent histone deacetylases (HDACs). These proteins play a key role in epigenetic regulation, which refers to changes in gene expression that are not due to alterations in DNA sequence. SIRT2 is involved in regulating many cellular processes, including cell division, DNA repair, and metabolism. One of the primary functions of SIRT2 is the deacetylation of histones, which are proteins that help package DNA into the compact structure of chromatin. SIRT2 has been implicated in several diseases, including cancer, neurodegeneration, and metabolic disorders. For example, in cancer, SIRT2 has been shown to have both tumor-promoting and tumor-suppressing effects, depending on the context. In neurodegenerative diseases such as Alzheimer's and Parkinson's, SIRT2 appears to play a role in the aggregation of misfolded proteins.
Target class
Epigenetic
Family
Accession number
NP_036369.2
Target Name
Sirtuin 2
Target Alias
Origin
Human
Theori. MW
37.3 kDa
Affinity tag
6His
Product specifications
Expression system
Expressed in E. coli
Purity
Refer to CoA for Purity
Purification method
Immobilised metal affinity chromatography
Sample Buffer
Protein in 25mM Hepes/NaOH pH7.4,
50mM NaCl, 50% glycerol. Frozen solution.
Specified activity
Refer to CoA
Application
For Research Only
Storage conditions
1 year at -70°C.
Usage disclaimer
For Research Only
Chemical data
Background
Sirtuin 2 (SIRT2) is a member of the Sirtuin family of NAD+-dependent histone deacetylases (HDACs). These proteins play a key role in epigenetic regulation, which refers to changes in gene expression that are not due to alterations in DNA sequence. SIRT2 is involved in regulating many cellular processes, including cell division, DNA repair, and metabolism. One of the primary functions of SIRT2 is the deacetylation of histones, which are proteins that help package DNA into the compact structure of chromatin. SIRT2 has been implicated in several diseases, including cancer, neurodegeneration, and metabolic disorders. For example, in cancer, SIRT2 has been shown to have both tumor-promoting and tumor-suppressing effects, depending on the context. In neurodegenerative diseases such as Alzheimer's and Parkinson's, SIRT2 appears to play a role in the aggregation of misfolded proteins.
Compound name
Epigenetic
Catalog number
EPI060
Molecular formula
CAS
MW
Ka
Percent composition
Product specifications
Physical state
Purity (HPLC 214nm)
Retention time (RP18 HPLC)
CMC
Exact mass
Stability
For Research Only
Solubility structure
Datasheets
EPI060
Datasheet