SUV39H2
Recombinant human SUV39H2 amino acids 114-410.
Biological information
Background
SUV39H2 (Suppressor of variegation 3-9 homolog 2) is a histone methyltransferase that plays a key role in the regulation of gene expression through the modification of chromatin structure. Specifically, SUV39H2 catalyzes the transfer of methyl groups to the lysine 9 residue of histone H3, leading to the formation of H3K9me3, a repressive chromatin mark that is associated with transcriptional silencing. SUV39H2 is involved in the regulation of various cellular processes, including cell differentiation, DNA damage response, and maintenance of genomic stability. It also plays a role in X-chromosome inactivation in female mammals, where it is responsible for the establishment and maintenance of heterochromatin at the inactive X chromosome. SUV39H2 is an important histone methyltransferase that plays a critical role in the regulation of gene expression and the maintenance of chromatin structure.
Target class
Epigenetic
Family
Accession number
NP_001180353.1
Target Name
SUV39H2
Target Alias
Origin
Human
Theori. MW
34 kDa
Affinity tag
Thrombin protease
Product specifications
Expression system
Expressed in E. coli
Purity
Refer to CoA for Purity
Purification method
Immobilised metal affinity chromatography
Sample Buffer
Protein in 5mM Tris/HCl pH7.5, 250mM NaCl, 50% Glycérol. Frozen solution.
Specified activity
Refer to CoA
Application
For Research Only
Storage conditions
1 year at -70°C.
Usage disclaimer
For Research Only
Chemical data
Background
SUV39H2 (Suppressor of variegation 3-9 homolog 2) is a histone methyltransferase that plays a key role in the regulation of gene expression through the modification of chromatin structure. Specifically, SUV39H2 catalyzes the transfer of methyl groups to the lysine 9 residue of histone H3, leading to the formation of H3K9me3, a repressive chromatin mark that is associated with transcriptional silencing. SUV39H2 is involved in the regulation of various cellular processes, including cell differentiation, DNA damage response, and maintenance of genomic stability. It also plays a role in X-chromosome inactivation in female mammals, where it is responsible for the establishment and maintenance of heterochromatin at the inactive X chromosome. SUV39H2 is an important histone methyltransferase that plays a critical role in the regulation of gene expression and the maintenance of chromatin structure.
Compound name
Epigenetic
Catalog number
EPI065
Molecular formula
CAS
MW
Ka
Percent composition
Product specifications
Physical state
Purity (HPLC 214nm)
Retention time (RP18 HPLC)
CMC
Exact mass
Stability
For Research Only
Solubility structure
Datasheets
EPI065
Datasheet