SUV4-20H2
Recombinant human SUV4-20H2 amino acids 2-248.
Biological information
Background
SUV4-20H2 (Suppressor of variegation 4-20 homolog 2) is a histone methyltransferase that adds methyl groups to histone H4 lysine 20 (H4K20), leading to the formation of the repressive chromatin mark H4K20me2 and H4K20me3. SUV4-20H2 is one of two paralogs of SUV4-20H family, which also includes SUV4-20H1. SUV4-20H2 is involved in the regulation of various cellular processes, including DNA damage response, heterochromatin formation, and telomere maintenance. It has been shown to play a role in the recruitment of DNA damage response factors to chromatin after DNA damage, and in the establishment of heterochromatin domains at repetitive DNA sequences, including telomeres. SUV4-20H2 is an important histone methyltransferase that plays a critical role in the regulation of gene expression and the maintenance of chromatin structure.
Target class
Epigenetic
Family
Accession number
NP_116090.2
Target Name
SUV4-20H2
Target Alias
Origin
Human
Theori. MW
28.1 kDa
Affinity tag
TEV
Product specifications
Expression system
Expressed in E. coli
Purity
Refer to CoA for Purity
Purification method
Immobilised metal affinity chromatography
Sample Buffer
Protein in 5mM Tris/HCl pH7.5,
250mM NaCl, 1.1mM DTT,50% Glycérol. Frozen solution.
Specified activity
Refer to CoA
Application
For Research Only
Storage conditions
1 year at -70°C.
Usage disclaimer
For Research Only
Chemical data
Background
SUV4-20H2 (Suppressor of variegation 4-20 homolog 2) is a histone methyltransferase that adds methyl groups to histone H4 lysine 20 (H4K20), leading to the formation of the repressive chromatin mark H4K20me2 and H4K20me3. SUV4-20H2 is one of two paralogs of SUV4-20H family, which also includes SUV4-20H1. SUV4-20H2 is involved in the regulation of various cellular processes, including DNA damage response, heterochromatin formation, and telomere maintenance. It has been shown to play a role in the recruitment of DNA damage response factors to chromatin after DNA damage, and in the establishment of heterochromatin domains at repetitive DNA sequences, including telomeres. SUV4-20H2 is an important histone methyltransferase that plays a critical role in the regulation of gene expression and the maintenance of chromatin structure.
Compound name
Epigenetic
Catalog number
EPI067
Molecular formula
CAS
MW
Ka
Percent composition
Product specifications
Physical state
Purity (HPLC 214nm)
Retention time (RP18 HPLC)
CMC
Exact mass
Stability
For Research Only
Solubility structure
Datasheets
EPI067
Datasheet