Soft Proprietary Stabilization Reagents

CALXGLUK Reagent

CALIXAR’s CALXGLUK is a calixarene detergent that can be used to solubilize membrane protein as GPCR.  

Purchase CALXGLUK reagent

5,11,17-tris{2-[4-(β-D-glucopyranosyl)-1H-1,2,3-triazol-1-yl]ethyl}-25-monoheptoxy-26,27,28-trimethoxycalix[4]arene

Compound name: CALXGLUK

Catalogue number: CALXGLUK_10MG,
CALXGLUK_50MG,
CALXGLUK_100MG

Molec. Formula: C71H95N9O22

CAS: nd

MW: 1426.5 g/mol

pKa: na

Percent Composition: C, 59.78; H, 6.71; N, 8.84; O, 24.67

Physical state: Beige powder

Purity (HPLC, 214nm): <95%

Retention time (RP18 HPLC)b: tR = 13.4 min

CMC: 0.025 mM

Exact mass: 1425.6592

Stability: Store in <-20°C freezer out of direct light

Solubility Structure: Soluble in water (2.5mM), methanol and DMSO

Datasheet

€450.00 (10mg)

€ 1,200.00 (50mg)

€ 1,900.00 (100mg)

ships in 7 business days

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First in market

CALIXAR is the first to produce native, wild-type, unmutated and untruncated targets.

Better discovery

Develop reliable and effective drugs and antibodies as they are not locked in any specific conformation.

Why choose us?

We practice a sole & custom-made approach to give you the edge

CALIXAR’s CALXGLUK is a very gentle detergent used to stabilize native membrane proteins. CALXGLUK is non-ionic and hence is not sensitive to ionic strength or pH fluctuations is well adapted to stabilize many different specific membrane proteins.

Calixar’s CALXGLUK can help deliver lipid detergent mixed micelles and protein detergent micelles. CALXGLUK also provides for the stabilization of native and functional membrane proteins within a solution.

Our CALXGLUK is provided in a powder form and is used in an aqueous solution or buffer which can also be mixed within biological substances (biological membranes).

CALXGLUK is a non-ionic calixarene based detergent / surfactant with three polar glucose groups and a heptyl chain.

CALIXAR’s CALXGLUK is non-ionic and therefore is not sensitive to ionic strength or pH variations and is able to stabilize specific membrane proteins. Due to the fluorinated chain, CALXGLUK does not solubilize lipid membranes.

CALIXAR’s CALXGLUK is a high-quality detergent / reagent utilized for research, drug discovery projects, and structural studies. Our technology is adapted for use in pharmaceutical and biotechnology companies, as well as for life science ​academic teams (biochemists, structural biologists, pharmacologists, virologists).

  • Antibodies (including nanobodies, scaffold proteins, aptamers)
  • Small molecules
  • 3D Structures (cryoEM, XRay crystallography, NMR, SANS, SAXS)
  • Drug discovery (Screening: HTS, FBDD, SBDD; Hit and lead validation)
  • Antibody discovery (Immunization and display technologies)
  • Clinical stage (drug validation on reliable native DDLAC)

References

Proprietary patent

Synthesis of amphiphilic calixarene glycoside detergents and use of same for extracting and stabilizing native functional membrane proteins

Read more

Contact us

Secure and boost your discovery programs.

Starting from native material or recombinant systems, we succeed with all types of membrane proteins: GPCRs, Ions Channels, Transporters, Receptors and Viral Proteins.

  • Conformational antibody development
  • Vaccine development
  • High-throughput ligand screening
  • Structure-based drug discovery
  • Immunoassays
  • Deorphanization projects
  • Identification of relevant targets
  • Expression of full-length membrane proteins
  • Functional isolation and stabilization of targets

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