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CALXGLUK

CALXGLUK stabilizing reagent

Biological information

Background
CALXGLUK or 5,11,17-tris{2-[4-(β-D-glucopyranosyl)-1H-1,2,3-triazol-1-yl]ethyl}-25- monoheptoxy-26,27,28-trimethoxycalix[4]arene stabilizing reagent is a calixarene detergent that can be used to solubilize membrane protein as GPCR. CALXGLUK is non-ionic with three polar glucose groups and a heptyl chain. Therefore, it is not sensitive to ionic strength or pH variations and is able to stabilize specific membrane proteins. Due to the fluorinated chain, CALXGLUK does not solubilize lipid membranes. CALXGLUK is a very gentle detergent provided in a powder form and is used in an aqueous solution or buffer which can also be mixed within biological substances (biological membranes). This detergent can help deliver lipids-detergents mixed micelles and protein detergent micelles. CALXGLUK also provides for the stabilization of native and functional membrane proteins within a solution. It can be utilized for research, drug discovery projects, and structural studies.
Target class
Stabilizing Reagents
Family
Accession number
Target Name
CALXGLUK
Target Alias
Origin
Theori. MW
Affinity tag

Product specifications

Expression system
Purity
Purification method
Sample Buffer
Specified activity
Application
For Research Only
Storage conditions
Store in < -20 °C freezer out of direct light for a long-term storage
Usage disclaimer
For Research Only

Chemical data

Background
CALXGLUK or 5,11,17-tris{2-[4-(β-D-glucopyranosyl)-1H-1,2,3-triazol-1-yl]ethyl}-25- monoheptoxy-26,27,28-trimethoxycalix[4]arene stabilizing reagent is a calixarene detergent that can be used to solubilize membrane protein as GPCR. CALXGLUK is non-ionic with three polar glucose groups and a heptyl chain. Therefore, it is not sensitive to ionic strength or pH variations and is able to stabilize specific membrane proteins. Due to the fluorinated chain, CALXGLUK does not solubilize lipid membranes. CALXGLUK is a very gentle detergent provided in a powder form and is used in an aqueous solution or buffer which can also be mixed within biological substances (biological membranes). This detergent can help deliver lipids-detergents mixed micelles and protein detergent micelles. CALXGLUK also provides for the stabilization of native and functional membrane proteins within a solution. It can be utilized for research, drug discovery projects, and structural studies.
Compound name
Stabilizing Reagents
Catalog number
40-S101P-10MG
Molecular formula
C71H95N9O24
CAS
nd
MW
1426.5 g/mol
Ka
na
Percent composition
C, 59.78; H, 6.71; N, 8.84; O, 24.67

Product specifications

Physical state
Beige powder
Purity (HPLC 214nm)
<95%
Retention time (RP18 HPLC)
13.4 min
CMC
0.025 mM
Exact mass
1425.6592 g/mol
Stability
For Research Only
Solubility structure
Soluble in water (0.025mM), methanol and DMSO.
Datasheets
40-S101P
Datasheet
€ 495,00 EUR
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