Soft Proprietary Stabilization Reagents

DDLAC Reagent

DDLAC is a non-ionic detergent / surfactant with a lactobionamide head group and a dodecyl chain.

Purchase DDLAC Reagent

N-dodecylamine lactobionamide

Compound name: N-dodecylamine lactobionamide (DDLAC)

Catalogue number: DDLAC_250MG
DDLAC_500MG
DDLAC_1G

Molec. Formula: C24H47NO11

CAS: nd

MW: 525.6 g/mol

pKa: na​

Percent Composition: C, 54.84; H, 9.01; N, 2.66; O, 33.48

Physical state: White powder

Purity (HPLC, 214nm): ≤95%

Retention time (RP18 HPLC)b: tR = 14.9 min

CMC: 0.25 mM

Exact mass​: 525.3149

Stability: Store in <-20°C freezer for up to one year

Solubility Structure: Soluble in water (1.25mM), methanol and DMSO

Datasheet

€ 150.00 (250mg)

ships in 7 business days

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First in market

CALIXAR is the first to produce native, wild-type, unmutated and untruncated targets.

Better discovery

Develop reliable and effective drugs and antibodies as they are not locked in any specific conformation.

Why choose us?

We use a unique & custom-built approach to give you an edge

CALIXAR’s DDLAC is produced into a powder form and is utilized in an aqueous solution or buffer. DDLAC can be mixed with biological materials (biological membranes).

Our clients are able to use DDLAC to aid in the production of lipid detergents, mixed micelles, and protein detergent micelles. DDLAC enables clients to extract, to solubilize and to stabilize native and functional membrane proteins of high medical relevance within a solution.

DDLAC is a fairly mild detergent used to solubilize and stabilize native membrane proteins that are non-ionic. Consequently, as it is not sensitive to ionic strength or pH variations, they are ideal to extract precise membrane proteins.

CALIXAR’s DDLAC is non-ionic and therefore not sensitive to ionic concentration or pH shifts.  DDLAC is well adapted to extract, to solubilize and to stabilize particular membrane proteins.

CALIXAR’s DDLAC (N-dodecylamine lactobionamide) extracts high-quality membrane proteins used for research, drug discovery and structural studies. Our DDLAC is specifically made for pharmaceutical and biotechnology companies, as well as academic teams (biochemists, structural biologists, pharmacologists, virologists) involved in the life science domains.

  • Antibodies (including nanobodies, scaffold proteins, aptamers)
  • Small molecules
  • 3D Structures (cryoEM, XRay crystallography, NMR, SANS, SAXS)
  • Drug discovery (Screening: HTS, FBDD, SBDD; Hit and lead validation)
  • Antibody discovery (Immunization and display technologies)
  • Clinical stage

References

ACS Publications

Lactobionamide Surfactants with Hydrogenated, Perfluorinated or Hemifluorinated Tails

Lebaupain F. et al. 2006

Read more

Contact us

Secure and boost your discovery programs.

Starting from native material or recombinant systems, we succeed with all types of membrane proteins: GPCRs, Ions Channels, Transporters, Receptors and Viral Proteins.

  • Conformational antibody development
  • Vaccine development
  • High-throughput ligand screening
  • Structure-based drug discovery
  • Immunoassays
  • Deorphanization projects
  • Identification of relevant targets
  • Expression of full-length membrane proteins
  • Functional isolation and stabilization of targets

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Membrane Protein Purchase

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Or leave us an email : contact(at)calixar.com