Soft Proprietary Stabilization Reagents

FTAC6 Reagent

CALIXAR’s FTAC6 Reagent is a non-ionic detergent that is primarily used to extract, solubilize and stabilize GPCRs, Ion channels, and Transporters.

Purchase FTAC6 Reagent

S-(poly(tris(hydroxymethyl)acrylamidomethane)-(3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorothiooctyl) DPn=6

Compound name: FTAC6

Catalogue number: FTAC6_250MG,
FTAC6_500MG,
FTAC6_1G

Molec. Formula: C6F13CH2CH2CH2

CAS: nd

MW: ≈1400 g/mol

pKa: na​

Percent Composition: na

Physical state: White powder

Purity (HPLC, 214nm): nd

Retention time (RP18 HPLC)b: tR = 10.5 min min

CMC: 0.37 mM

Exact mass: nd

Stability: Store in <-20°C freezer out of direct light

Solubility Structure: Soluble in water (18.5mM), methanol and DMSO

Datasheet

€ 150.00 (250mg)

ships in 7 business days

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First in market

CALIXAR is the first to produce native, wild-type, unmutated and untruncated targets.

Better discovery

Develop reliable and effective drugs and antibodies as they are not locked in any specific conformation.

Why choose us?

We use a novel & custom-produced method to give you the edge

CALIXAR’s FTAC6 is a very soft detergent used to stabilize native membrane proteins. FTAC6 is non-ionic and therefore not sensitive to ionic strength or pH variations is well adapted to stabilize many different specific membrane proteins. Due to the fluorinated chain, FTAC6 is poorly delipidating towards membrane proteins.

Our FTAC6 can improve the production of lipid detergents, mixed micelles, and protein detergent micelles. FTAC6 allows for the stabilization of native and functional membrane proteins in a solution.

Our FTAC6 is provided in powder form and will be used in an aqueous solution or buffer and can also be mixed within biological materials (biological membranes).

CALIXAR’s FTAC6 is non-ionic and consequently not sensitive to ionic strength or pH fluctuations and is able to stabilize specific membrane proteins. Due to the fluorinated chain, FTAC6 does not solubilize lipid membranes.

CALIXAR’s FTAC6 is a high-quality detergent / reagent used for research and pharmaceutical discovery projects. Our structural studies and are adapted for use in biotechnology companies, as well as for academic teams (biochemists, structural biologists, pharmacologists, virologists) involved in the life science fields.

  • Antibodies (including nanobodies, scaffold proteins, aptamers)
  • Small molecules
  • 3D Structures (cryoEM, XRay crystallography, NMR, SANS, SAXS)
  • Drug discovery (Screening: HTS, FBDD, SBDD; Hit and lead validation)
  • Antibody discovery (Immunization and display technologies)
  • Clinical stage (drug validation on reliable native DDLAC)

References

Febs Letters

New tensio-active molecules stabilize a human G protein-coupled receptor in solution.

Damian, M. et al. 2007

Read more

Biochimica Et Biophysica Acta-Biomembranes

Functional studies of membrane-bound and purified human Hedgehog receptor Patched expressed in yeast.

Joubert O. et al. 2009

Read more

Biochemical Journal

Fluorinated and hemifluorinated surfactants as alternatives to detergents for membrane protein cell-free synthesis

Park K.-H. et al. 2007

Read more

Contact us

Secure and boost your discovery programs.

Starting from native material or recombinant systems, we succeed with all types of membrane proteins: GPCRs, Ions Channels, Transporters, Receptors and Viral Proteins.

  • Conformational antibody development
  • Vaccine development
  • High-throughput ligand screening
  • Structure-based drug discovery
  • Immunoassays
  • Deorphanization projects
  • Identification of relevant targets
  • Expression of full-length membrane proteins
  • Functional isolation and stabilization of targets

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