Soft Proprietary Stabilization Reagents

FTAC8 Reagent

FTAC8 is a non-ionic detergent that is principally used to extract, solubilize and stabilize GPCRs, Ion channels, and Transporters.

Purchase FTAC8 reagent

S-(poly(tris(hydroxymethyl)acrylamidomethane)- (3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorothiodecyl) DPn=12

Compound name: FTAC8

Catalogue number: FTAC8_250MG,
FTAC8_500MG,
FTAC8_1G

Molec. Formula: C8F17CH2CH2

CAS: nd

MW: ≈2600 g/mol

pKa: na

Percent Composition: na

Physical state: White powder

Purity (HPLC, 214nm): nd

Retention time (RP18 HPLC)b: tR = 11.7 min min

CMC: 0.02 mM

Exact mass: nd

Stability: Store in <-20°C freezer for up to one year

Solubility Structure: Soluble in water (1mM), methanol and DMSO

€ 150.00 (250mg)

ships in 7 business days

First in market

CALIXAR is the first to produce native, wild-type, unmutated and untruncated targets.

Better discovery

Develop reliable and effective drugs and antibodies as they are not locked in any specific conformation.

Why choose us?

We use proprietary technology & custom-built approaches to give you the edge

CALIXAR’s FTAC8 is a rather mild detergent utilized to stabilize native membrane proteins. FTAC8 is non-ionic and therefore not susceptible to ionic strength fluctuations or pH variations. They are also well suited to stabilize many different particular membrane proteins. Due to the fluorinated chain, FTAC8 is poorly delipidating towards membrane proteins.

Our FTAC8 helps generate lipid detergent mixed micelles and protein detergent micelles. FTAC8 also allows for the stabilization of native and functional membrane proteins. It is also used as a protein chaperone to inject membrane proteins into liposomes.

CALIXAR’s FTAC8 is provided in powder form and is generally used in an aqueous solution or buffer. It can also be mixed within biological materials (biological membranes).

CALIXAR’s FTAC8 is non-ionic detergent and therefore is not susceptible to ionic strength variations or pH fluctuations. It is also able to stabilize specific membrane proteins due to the fluorinated chain. FTAC8 does not solubilize the lipid membrane.

CALIXAR’s FTAC8 is a leading-quality detergent / reagent principally used in research and drug discovery projects. Our structural studies and are adapted for use in pharmaceutical and biotechnology companies, as well as for life science academic teams (biochemists, structural biologists, virologists, pharmacologists).

  • Antibodies (including nanobodies, scaffold proteins, aptamers)
  • Small molecules
  • 3D Structures (cryoEM, XRay crystallography, NMR, SANS, SAXS)
  • Drug discovery (Screening: HTS, FBDD, SBDD; Hit and lead validation)
  • Antibody discovery (Immunization and display technologies)
  • Clinical stage (drug validation on reliable native DDLAC)

References

Febs Letters

New tensio-active molecules stabilize a human G protein-coupled receptor in solution.

Damian M. et al. 2007

Biochimica Et Biophysica Acta-Biomembranes

Functional studies of membrane-bound and purified human Hedgehog receptor Patched expressed in yeast.

Joubert O. et al. 2009

Biochemical Journal

Fluorinated and hemifluorinated surfactants as alternatives to detergents for membrane protein cell-free synthesis

Park K.-H. et al. 2007

Membrane Protein Purchase

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Give us a call : +33 481 076 460

Or leave us an email : contact(at)calixar.com