CALIXAR's Membrane Protein GPCR Targets

CALIXAR’s Membrane Protein GPCR targets listed below, are continuously being optimized in our laboratories and are already available for purchase from our expanding catalog.

CALIXAR offers full-length, native, and functional GPCRs.

We overexpress, solubilize, stabilize and purify our GPCRs with our patented technologies, so we can offer you the highest quality proteins. We use standard quality tests to confirm :

  • Purity (SDS-PAGE, UV Spectrum…)
  • Stability (Thermal Shift Assay, Cryo-Stability Assay…)
  • Homogeneity (SEC, DLS…)
  • Functionality (Ligand Binding Assay, Ion Flux Assay, Enzymatic Activity…)


Our GPCRs are the best source for functional, structural, or identification assays, as they are strictly identical to the ones in membranes. Our membrane proteins can be extracted from different expression systems (human, insect, and yeast cells, bacteria, virus…)

Here are some of our GPCR membrane targets that are currently available for purchase from CALIXAR.


Most frequent questions and answers

G protein-coupled receptors (GPCR) are one of the largest families of integral membrane proteins. More than 700 genes are identified as G-protein coupled receptors. As the name suggests, the binding of an agonist to the GPCR receptor results in the recruitment and activation of the G protein, or of other transducers like arrestins.

GPCRs are specific to a wide range of ligands, including photons, small molecules, and proteins. When the receptor is activated by an agonist, its conformation is altered in a ligand-dependent manner, triggering specific modulation and activation of G proteins in the cell.

An active G protein can induce various intracellular messenger cascades, allowing the regulation of an incredible array of functions in the human body. GPCRs-driven signaling pathways are involved in pretty much every physiological function and in many pathologies including Parkinson’s disease, Alzheimer’s disease, and Schizophrenia. They are the target of about 34% of modern drugs.

CALIXAR provides native Membrane Protein GPCR Targets in full-length form, and without mutation. Their purity is higher than 90% and their stability allows them to be used in many different life science projects.

GPCRs play a vital role in interfering with a wide variety of physiological events, from sensory modulations to hormonal responses.

They are particularly involved in many diseases of the central nervous system (CNS). CALIXAR’s Membrane Protein GPCR Targets can be used to develop and test new and innovative drugs.

CALIXAR’s Membrane Protein GPCR Targets are ideal for all actors involved in any life science projects who can benefit from purified membrane proteins. This includes pharmaceutical companies, biotechnology companies, and academic research centers.

Our GPCRs are most suited for these types of life science projects:

G-protein coupled receptors (GPCRs) are exceptionally useful in the innovative work of drug discovery and development. By using the native full-length GPCRs produced by CALIXAR in their R&D studies, pharmaceutical and biotech companies will be able to develop their portfolio of therapeutics with the guarantee that they have been developed using highly pure and mutation-free receptors. As a result, all companies in life science projects can work with highly reliable biological material.

GPCRs are unstable targets and it’s difficult to produce them natively. The challenge of CALIXAR is to provide GPCR targets with whole structural and functional integrity, that are able to bind to agonists and antagonists. These targets allow the ability to conduct life science projects and obtain successful results due to purified and stabilized membrane proteins used.

Due to the instability of GPCRs targets, CALIXAR has taken up the challenge to provide the most stable and native GPCRs membrane proteins. CALIXAR’s membrane proteins GPCR targets are produced in their native conformity with a high level of purity, without truncation or mutation. These are the first wild-type and pure GPCRs on the target we can participate in many discovery programs due to the wide range of physiological and metabolic functions.