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MT1R, ACTIVE

Recombinant human Melatonin receptor type 1A (MTNR1A) full-length, wildtype sequence N-terminus twin Strep tag II, 10xHis-tag, TEV protease cleavage site

Biological information

Background
MTR1A (Melatonin receptor type 1A) helps you identify, develop, and test new molecules and therapeutic antibodies. Our Melatonin receptor type 1A (MTR1A) is a class A GPCR that modulates neuronal firing, arterial vasoconstriction, cell proliferation in cancer cells, and reproductive and metabolic functions.Melatonin receptor type 1A is a powerful therapeutic candidate for insomnia, circadian sleep disorders, depression, cardiovascular regulation, cancer, and neurodegenerative diseases. Its function is modulated by G proteins sensitive to pertussis toxin, which suppress the activity of adenylate cyclase. Our Melatonin receptor type 1A is produced in a eukaryotic arrangement with the precise post-translational adjustments (glycosylation). MTR1A is able to bind to agonists, antagonists, as well as allosteric modulators and preserve their structural and functional integrity. They are purified and stabilized to full length and wild-type (native) proteins. This protein aids in reliable fragment-based drug design (FBDD), structure-based drug discovery (SBDD) and antibody discovery against this specific target.
Target class
GPCR
Family
Class A GPCR
Accession number
P48039
Target Name
MT1R, ACTIVE
Target Alias
Mel-1A-R; Mel1a receptor
Origin
Human
Theori. MW
44,8 kDa
Affinity tag
Twin Strep tag II, 10xHis-tag

Product specifications

Expression system
Expressed in baculovirus in Sf9 insect cells
Purity
Purity >90% by SDS-PAGE with Stain-FreeTM detection
Purification method
Solubilized using Eurofins CALIXAR patented technology and purified using Metal Affinity Chromatography in presence of Sarkosyl/CHS
Sample Buffer
Protein in 25mM Na2HPO4 pH 8.0, 150mM NaCl, 0.86%/0.18% Sarkosyl/CHS
Specified activity
Confirmed by radiobinding assay and activation of Gi
Application
For Research Only
Storage conditions
Store at -80°C
Usage disclaimer
For Research Only

Chemical data

Background
MTR1A (Melatonin receptor type 1A) helps you identify, develop, and test new molecules and therapeutic antibodies. Our Melatonin receptor type 1A (MTR1A) is a class A GPCR that modulates neuronal firing, arterial vasoconstriction, cell proliferation in cancer cells, and reproductive and metabolic functions.Melatonin receptor type 1A is a powerful therapeutic candidate for insomnia, circadian sleep disorders, depression, cardiovascular regulation, cancer, and neurodegenerative diseases. Its function is modulated by G proteins sensitive to pertussis toxin, which suppress the activity of adenylate cyclase. Our Melatonin receptor type 1A is produced in a eukaryotic arrangement with the precise post-translational adjustments (glycosylation). MTR1A is able to bind to agonists, antagonists, as well as allosteric modulators and preserve their structural and functional integrity. They are purified and stabilized to full length and wild-type (native) proteins. This protein aids in reliable fragment-based drug design (FBDD), structure-based drug discovery (SBDD) and antibody discovery against this specific target.
Compound name
GPCR
Catalog number
41-G102A-10UG
Molecular formula
CAS
MW
Ka
Percent composition

Product specifications

Physical state
Purity (HPLC 214nm)
Retention time (RP18 HPLC)
CMC
Exact mass
Stability
For Research Only
Solubility structure
Datasheets
41-G102A
Datasheet
€ 1 100,00 EUR
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